Synthetic approach to quinocarcin |
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| Affiliation: | 1. Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale Andrea Doria 6, I-95125 Catania, Italy;2. Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Risorgimento, 35, I-56126 Pisa, Italy;3. Laboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain;4. Laboratory for Chemometrics and Cheminformatics, Chemistry Department, University of Perugia, Via Elce di Sotto 10, I-06123 Perugia, Italy;5. Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Sez. Chimica, Università degli Studi di Palermo, Viale delle Scienze Ed. 17—Parco D’Orleans II, I-90128 Palermo, Italy;6. Istituto EuroMediterraneo di Scienza e Tecnologia (IEMEST), Via Emerico Amari 123, I-90139 Palermo, Italy;7. Dipartimento di Scienze della Salute, Università di Milano-Bicocca, Via Cadore 48, I-20900 Monza (MB), Italy;8. Dipartimento di Chirurgia e Medicina Traslazionale, Università di Milano-Bicocca, Via Cadore 48, I-20900 Monza (MB), Italy;1. Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, MD 20892-3373, United States;2. Center for Molecular Modeling, Office of Intramural Research, Center for Information Technology, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, United States;3. Psychobiology Section, Molecular Neuropsychiatry Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, United States;4. Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, United States;5. Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington DC 20375, United States;1. State Key Laboratory of Coordination Chemistry, Department of Polymer Science & Engineering, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, PR China;2. Department of Polymer Science & Engineering, Nanjing University, Nanjing 210093, PR China |
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| Abstract: | A basic synthetic route to quinocarcin is elaborated. The optically active basic skeleton of quinocarcin, iminoazepinoisoquinoline 1 was efficiently synthesized starting from phenylalanine and glutamic acid derivative. |
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