Synthesis of indolizines starting from pyrylium salts |
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| Institution: | 1. Inst. of Chemical and Pharmaceutical Research, Bucharest, Roumania;2. Polytechnic Inst., Organic Chemistry Dept., Spl. Independentei 303, 76206 Bucharest, Roumania;1. School of Biological Science & Medical Engineering, Southeast University, Si Pai Lou 2#, Nanjing City 210096, PR China;2. School of Chemistry & Chemical Engineering, Southeast University, Si Pai Lou 2#, Nanjing City 210096, PR China;3. Suzhou Key Laboratory of Biomaterials and Technologies & Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou 215123, PR China;1. Syngenta Crop Protection AG, Crop Protection Research, Research Chemistry, Schaffhauserstrasse 101, CH-4332, Switzerland;2. Bogazici University, Department of Chemistry, Bebek, 34342 Istanbul, Turkey;1. School of Physical Sciences, Jawaharlal Nehru University, New Delhi 110 067, India;2. Department of Chemistry, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh 495 009, India |
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| Abstract: | β-N-Pyridinium acetaldehydes with alkyl substituents in the 2 and 6 positions of the pyridinium ring, obtained from the corresponding pyrylium salts, cyclise in alkaline medium to new indolizines. This high-yield reaction sequence is optimal for indolizines unsubstituted in the five-membered ring which are difficultly accessible by other methods. |
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