New Clerodane Diterpenoids from Casearia membranacea |
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| Authors: | Ya‐Ching Shen,Cheng&#x Lin Lee,Ashraf&#x Taha Khalil,Yuan‐Bin Cheng,Ching‐Te Chien,Yao‐Haur Kuo |
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| Affiliation: | Ya‐Ching Shen,Cheng Lin Lee,Ashraf Taha Khalil,Yuan‐Bin Cheng,Ching‐Te Chien,Yao‐Haur Kuo |
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| Abstract: | Bioassay‐guided fractionation of an AcOEt extract of Casearia membranacea resulted in the isolation of six new clerodane diterpenes, caseamembrins G–L ( 1 – 6 ). The structures of the new compounds, including their relative configurations, were established by an extensive study of their spectral data, especially 2D NMR. The cytotoxic activities of the isolated diterpenes against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (Hep59T/VGH) carcinoma cell lines were investigated. |
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