Multicomponent assembly strategies for the synthesis of diverse tetrahydroisoquinoline scaffolds |
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| Authors: | Granger Brett A Kaneda Kyosuke Martin Stephen F |
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| Institution: | Department of Chemistry and Biochemistry, The Texas Institute for Drug and Diagnostic Development, The University of Texas at Austin, Austin, Texas 78712, USA. |
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| Abstract: | Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatization to access a diverse array of compounds. This work led to the serendipitous discovery of a new method for the synthesis of a fused quinazolone ring system, which was applied to a one-step total synthesis of the quinazolinocarboline alkaloid rutaecarpine. |
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