| 4(R)-(2,4,6-三甲基苄氧基)-(S)-脯氨酸促进的直接不对称羟醛反应 |
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| 引用本文： | 沈宗旋,丁一,李明,刘艳华,张雅文.4(R)-(2,4,6-三甲基苄氧基)-(S)-脯氨酸促进的直接不对称羟醛反应[J].有机化学,2005,25(9):1113-1115. |
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| 作者姓名： | 沈宗旋 丁一 李明 刘艳华 张雅文 |
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| 作者单位： | 1. 苏州大学化学化工学院江苏省有机合成重点实验室,苏州,215006
2. 江南大学化学和材料工程学院,无锡,214000 |
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| 摘 要： | 方便地合成了一种新的不对称羟醛反应的手性催化剂4(R)-(2,4,6-三甲基苄氧基)-(S)-脯氨酸. 以过量的丙酮作溶剂, 使用5 mol%该催化剂, 有效地催化了多种取代苯甲醛与丙酮间的不对称羟醛反应, 产率最高达91.0%, ee最高达84.3%.
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| 关 键 词： | 不对称 直接羟醛反应 手性催化剂 |
| 收稿时间： | 2004-9-27 |
| 修稿时间： | 2004年9月27日 |
Direct Catalytic Asymmetric Aldol Reactions Promoted by 4(R)-(2,4,6-Trimethylbenzyloxy)-(S)-proline |
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| SHEN,Zong-Xuan,DING,Yi,LI,Ming,LIU,Yan-Hua,ZHANG,Ya-Wen.Direct Catalytic Asymmetric Aldol Reactions Promoted by 4(R)-(2,4,6-Trimethylbenzyloxy)-(S)-proline[J].Chinese Journal of Organic Chemistry,2005,25(9):1113-1115. |
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| Authors: | SHEN Zong-Xuan DING Yi LI Ming LIU Yan-Hua ZHANG Ya-Wen |
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| Institution: | ( Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical En-gineering, Suzhou University, Suzhou 215006)( School of Chemical and Mate-rial Engineering, Southern Yantze University, Wuxi 214000) |
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| Abstract: | 4(R)-(2,4,6-Trimethylbenzyloxy)-(S)-proline, a new chiral catalyst for the asymmetric aldol re- action, was prepared conveniently. Efficient enantioselective catalysis of aldol reactions of various benzal- dehydes with neat acetone solvent was achieved with high yield (up to 91.0%) and good selectivities (up to 88.5% ee) by using 5 mol% of the catalyst. |
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| Keywords: | asymmetric direct aldol reaction chiral catalyst |
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