HPLC methods for therapeutic drug monitoring involving direct serum injection, column switching, and simple mobile phase adjustments

Conclusion The precision and accuracy of the HPLC methods appear to be sufficient for routine drug measurements. They show a good practicability, as mobile phase adjustments are part of the methods and no sample preparation is required. Although homogeneous non-isotopic immunoassays may be preferable for stat analyses, the described HPLC procedure is an attractive alternative for measuring several drugs and metabolites simultaneously in a single specimen. It is to be expected that numerous further drugs (e.g. anticonvulsants, antiarrhythmics) can be measured by this Chromatographic technique under similar conditions.

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HPLC-Methoden für das Drug-Monitoring mit direkter Seruminjektion, Säulenschaltung und einfacher Umstellung der mobilen Phasen