Unexpected copper-catalyzed aerobic oxidative cleavage of C(sp3)-C(sp3) bond of glycol ethers |
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| Authors: | Liu Zhong-Quan Zhao Lixing Shang Xiaojie Cui Zili |
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| Institution: | State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou Gansu 730000, PR China. liuzhq@lzu.edu.cn |
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| Abstract: | An unexpected Cu-catalyzed oxidative cleavage of the C(sp(3))-C(sp(3)) bond in glycol ethers by using air or molecular oxygen as the terminal stoichiometric oxidant is demonstrated. As a result, the corresponding α-acyloxy ethers and formates of 1,2-ethanediol are formed by direct coupling of carboxylic acids and aldehydes with glycol ethers under the reaction conditions. This method represents the first example of Cu-catalyzed aerobic cleavage of saturated C-C bond in ethers. |
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