Anodic polarographic determination of flucloxacillin |
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Authors: | Squella J A Silva M M Nuñez-Vergara L J |
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Affiliation: | Department of Chemical Pharmacology and Physical Chemistry, Faculty of Chemical and Pharmacological Sciences, P.O. Box 233, Santiago, Chile. |
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Abstract: | The hydrolysis of flucloxacillin at pH 4.9 yields a degradation product which is polarographically oxidizable. This derivative has not been identified, but would seem to contain a thiol group. It gives a diffusion-controlled anodic polarographic wave with a half-wave potential at -0.24 V vs. SCE. The method developed has been applied to the analysis of flucloxacillin capsules, and a recovery of 99% has been obtained. |
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