Asperflaloids A and B from Aspergillus flavipes DZ-3, an Endophytic Fungus of Eucommia ulmoides Oliver |
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| Authors: | Wan Liu Yu Liu Fan Yang Shouye Han Jia Zhang Hui Yang Zhongbin Cheng Qin Li |
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| Affiliation: | 1.School of Pharmacy, Henan University, Kaifeng 475004, China; (W.L.); (Y.L.); (F.Y.); (S.H.); (J.Z.);2.Eucommia Ulmoides Cultivation and Utilization of Henan Engineering Laboratory, Kaifeng 475004, China |
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| Abstract: | The fungus strain DZ-3 was isolated from twigs of the well-known medicinal plant Eucommia ulmoides Oliver and identified as Aspergillus flavipes. Two new alkaloids, named asperflaloids A and B (1 and 2), together with 10 known compounds (3–12) were obtained from the EtOAc extract of the strain. Interestingly, the alkaloids 1–4 with different frameworks are characterized by the presence of the same anthranilic acid residue. The structures were established by detailed analyses of the spectroscopic data. The absolute configuration of asperflaloids A and B was resolved by quantum chemistry calculation. All compounds were screened for their inhibitions against α-glucosidase and the antioxidant capacities. The results were that compound 3 had an IC50 value of 750.8 μM toward α-glucosidase, and the phenol compounds 7 and 8 exhibited potent antioxidant capacities with IC50 values 14.4 and 27.1 μM respectively. |
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| Keywords: | Aspergillus flavipes DZ-3, asperflaloids A and B, structural identification, bioactivity |
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