| 新型取代吲哚-3-甲醇类衍生物的合成 |
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| 引用本文： | 刘益州,王新颖,徐栋栋,郑程隆,康从民. 新型取代吲哚-3-甲醇类衍生物的合成[J]. 合成化学, 2017, 0(1). DOI: 10.15952/j.cnki.cjsc.1005-1511.2017.01.16125 |
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| 作者姓名： | 刘益州 王新颖 徐栋栋 郑程隆 康从民 |
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| 作者单位： | 青岛科技大学 化工学院,山东 青岛,266042 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 以取代吲哚为原料,经维尔斯迈尔-哈克反应制得取代吲哚-3-甲醛,再通过DMSO/NaOH体系制得N-取代吲哚-3-甲醛(3a~3g);3a~3g经Na BH4还原合成了7个未见文献报道的取代吲哚-3-甲醇类衍生物(4a~4g),其结构经~1H NMR,~(13)C NMR和MS表征。
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| 关 键 词： | 取代吲哚 吲哚-3-甲醛 维尔斯迈尔-哈克反应 还原反应 吲哚-3-甲醇 合成 |
Syntheses of Novel Indole-3-methanol Derivatives |
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| LIU Yi-zhou,WANG Xin-ying,XU Dong-dong,ZHENG Cheng-long,KANG Cong-min?. Syntheses of Novel Indole-3-methanol Derivatives[J]. Chinese Journal of Synthetic Chemistry, 2017, 0(1). DOI: 10.15952/j.cnki.cjsc.1005-1511.2017.01.16125 |
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| Authors: | LIU Yi-zhou WANG Xin-ying XU Dong-dong ZHENG Cheng-long KANG Cong-min? |
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| Abstract: | N-substituted indole-3-formaldehydes(3a~3g) were synthesized in the system of dimethyl sulfoxide and sodium hydroxide by reation of substituted indole-3-formaldehydes, which were obtained by Vilsmeier-Haack reaction of substituted indoles. Seven novel substituted indole-3-methanols were synthesized by reduction of 3a~3g with sodium borohydride as the reagent. The structures were char-acterizd by 1 H NMR, 13 C NMR and MS. |
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| Keywords: | substituted indole indole-3-formaldehyde Vilsmeier-Haack reaction reduction reaction indole-3-methanol synthesis |
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