| 维生素D_2-A和CD片段醇的合成工艺改进 |
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| 引用本文： | 陈光耀,鲍晓珍,丁颖,张衡瑞,方志杰. 维生素D_2-A和CD片段醇的合成工艺改进[J]. 合成化学, 2017, 25(2). DOI: 10.15952/j.cnki.cjsc.1005-1511.2017.02.16225 |
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| 作者姓名： | 陈光耀 鲍晓珍 丁颖 张衡瑞 方志杰 |
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| 作者单位： | 南京理工大学 化工学院,江苏 南京,210094 |
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| 基金项目： | 江苏省产学研联合创新资金前瞻性联合研究项目，南京理工大学研究生科研创新计划项目，南京理工大学本科生科研训练"百千万"计划江苏省级项目 |
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| 摘 要： | 以维生素D_2(V-D_2)为原料,经高锰酸钾氧化、选择性切断和还原反应同时合成了维生素D_2-A(总产率30%)和CD片段醇(总产率45%),其结构经~1H NMR确证。
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| 关 键 词： | 维生素D2 VD2-CD片段 合成 工艺改进 |
Process Improvement on Synthesis of Vitamin D2-A and CD Ring Fragment Alcohol |
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| CHEN Guang-yao,BAO Xiao-zhen,DING Ying,ZHANG Heng-rui,FANG Zhi-jie. Process Improvement on Synthesis of Vitamin D2-A and CD Ring Fragment Alcohol[J]. Chinese Journal of Synthetic Chemistry, 2017, 25(2). DOI: 10.15952/j.cnki.cjsc.1005-1511.2017.02.16225 |
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| Authors: | CHEN Guang-yao BAO Xiao-zhen DING Ying ZHANG Heng-rui FANG Zhi-jie |
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| Abstract: | Both vitamin D2-A and CD ring fragment alcohols were synthesized by permanganate oxida-tion, selective bond cleavage and reduction from vitamin D2 . The total yield of D2-A and CD ring alco-hol were 30% and 45%, respectively. The structures were confirmed by 1 H NMR. |
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| Keywords: | vitamin D2 VD2-CD ring-fragment synthesis process improvement |
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