| 新型N-芳基哌嗪取代苯并呋喃衍生物的合成 |
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| 引用本文： | 毛泽伟,虎春艳,陈文君,余珏,林玉萍. 新型N-芳基哌嗪取代苯并呋喃衍生物的合成[J]. 合成化学, 2017, 0(1). DOI: 10.15952/j.cnki.cjsc.1005-1511.2017.01.16167 |
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| 作者姓名： | 毛泽伟 虎春艳 陈文君 余珏 林玉萍 |
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| 作者单位： | 云南中医学院 中药学院,云南 昆明,650500 |
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| 基金项目： | 云南省教育厅科学研究基金资助项目 |
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| 摘 要： | 以5-二甲氨基水杨醛和2-溴-4'-氟苯乙酮为原料,经缩合和取代反应制得中间体6-二乙氨基-2-[4'-(N-哌嗪基)苯甲酰基]苯并呋喃(2);2与卤代烃反应合成了6个新型的N-芳基哌嗪取代苯并呋喃衍生物(4a~4f),收率76%~93%,其结构经1H NMR,13C NMR和HR-MS(ESI-TOF)表征。
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| 关 键 词： | 5-二甲氨基水杨醛 2-溴-4′-氟苯乙酮 N-芳基哌嗪 苯并呋喃衍生物 合成 |
Synthesis of Novel N-aryl Piperazine Substituted Benzofuran Derivatives |
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| MAO Ze-wei,HU Chun-yan,CHEN Wen-jun,YU Jue,LIN Yu-ping?. Synthesis of Novel N-aryl Piperazine Substituted Benzofuran Derivatives[J]. Chinese Journal of Synthetic Chemistry, 2017, 0(1). DOI: 10.15952/j.cnki.cjsc.1005-1511.2017.01.16167 |
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| Authors: | MAO Ze-wei HU Chun-yan CHEN Wen-jun YU Jue LIN Yu-ping? |
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| Abstract: | The intermediate 6-diethylamino-2-[ 4′-( N-piperazinyl ) benzoyl ] benzofuran ( 2 ) was ob-tained by the reaction of condensation and substitution, using 5-diethylaminosalicylaldehyde and 2-bro-mo-4′-fluoroacetophenone as materials. Six novel N-aryl piperazine substituted benzofuran derivatives (4a~4f) with yields of 76% ~93% were synthesized by the reaction of 2 with halohydrocarbons. The structures were characterized by 1 H NMR, 13 C NMR and HR-MS( ESI-TOF) . |
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| Keywords: | 5-diethylaminosalicylaldehyde 2-bromo-4′-fluoroacetophenone N-aryl piperazine benzo-furan derivative synthesis |
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