| 碳酸钾与相转移催化剂催化的硝基甲烷与α,β-不饱和酰基吡唑的Michael加成反应 |
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| 引用本文： | 张辉,刘司洋,叶玲,薛泽理,丁路嘉,唐婷,陈峰,李雪锋.碳酸钾与相转移催化剂催化的硝基甲烷与α,β-不饱和酰基吡唑的Michael加成反应[J].合成化学,2017,25(4). |
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| 作者姓名： | 张辉 刘司洋 叶玲 薛泽理 丁路嘉 唐婷 陈峰 李雪锋 |
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| 作者单位： | 1. 西南民族大学化学与环境保护工程学院,四川 成都,610041;2. 西南交通大学地球科学与环境工程学院,四川 成都,610031 |
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| 基金项目： | 西南民族大学2015年省级大学生创新创业训练计划项目，四川省科技厅应用基础研究计划项目 |
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| 摘 要： | 在碳酸钾和18-冠-6的共同催化下,低活性的Michael受体α,β-不饱和酰基吡唑顺利与硝基甲烷发生Michael加成反应,以31%~78%收率合成了5个4-硝基-丁酰基-3,5-二甲基吡唑,其中4个为新化合物,其结构经~1H NMR,~(13)C NMR和HR-MS(ESI)表征。
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| 关 键 词： | α β-不饱和酰基吡唑 硝基甲烷 18-冠-6 催化 Michael加成 合成 |
Michael Addition of Nitromethane to α,β-Unsaturated Pyrazolamides Catalyzed by Potassium Carbonate and Phase-Transfer Catalyst |
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| ZHANG Hui,LIU Si-yang,YE Ling,XUE Ze-li,DING Lu-jia,TANG Ting,CHEN Feng,LI Xue-feng.Michael Addition of Nitromethane to α,β-Unsaturated Pyrazolamides Catalyzed by Potassium Carbonate and Phase-Transfer Catalyst[J].Chinese Journal of Synthetic Chemistry,2017,25(4). |
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| Authors: | ZHANG Hui LIU Si-yang YE Ling XUE Ze-li DING Lu-jia TANG Ting CHEN Feng LI Xue-feng |
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| Abstract: | An efficient protocol for the Michael addition of nitromethane to α,β-unsaturated pyrazolamides was reported.The Michael reaction proceeded smoothly in the presence of a combination of potassium carbonate and 18-crown-6, and five 4-nitrobutanoyl-3,5-dimethylpyrazoles with the yield of 31%~78% were synthesized, amomg them four were novel compounds.The structures were characterized by 1H NMR, 13C NMR, and HR-MS(ESI). |
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| Keywords: | α β-unsaturated pyrazolamide nitromethane 18-crown-6 catalysis Michael addition synthesis |
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