Bio-sensing on a chip with compact discs and nanofibers |
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Authors: | Tabuchi Mari Kobayashi Kazuyoshi Fujimoto Masayuki Baba Yoshinobu |
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Institution: | Department of Molecular and Pharmaceutical Biotechnology, Graduate School of Pharmaceutical Science, The University of Tokushima COE, 1-78 Shomachi, Tokushima 770-8505, Japan. tabuchi@ph.tokushima-u.ac.jp |
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Abstract: | This paper describes a novel, sensitive detection system for biomolecules (DNA and proteins etc.) that is integrated in a lab-on-a-chip utilizing optical compact discs (CDs) and bio-nanofibers. The new method comprises a microchannel containing CD grating that confines fragments of unique bacterial cellulose fibrils (BC), which have nanometre scale fibers and holes. A maximum of six times higher sensitivity to detect DNA was obtained with this CD and BC system compared to a conventional method. We also demonstrate an effective light-confining effect for biological application with the new method. |
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