MRI in children with postinfectious disseminated encephalomyelitis |
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| Authors: | V Dun J F Bale R A Zimmerman Z Perdue W E Bell |
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| Affiliation: | 1. UMRi CNRS 7266 LIENSs, University of La Rochelle, 17042 La Rochelle, France;2. Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, 56306-000 Petrolina, Brazil;3. UMR CNRS 8638 Laboratory of Pharmacognosy, Paris Descartes University, 75006 Paris, France;1. Dell Seton Medical Center at the University of Texas, Department of Pharmacy, 1500 Red River Street, Austin, TX 78701;2. St. David’s Healthcare, St. David’s South Austin Medical Center, Department of Pharmacy, 901 W. Ben White Blvd., Austin, TX 78704;3. Dell Seton Medical Center at the University of Texas, Laboratory Administration, 1500 Red River Street, Austin, TX 78701;1. Biology Department, Science and Arts University, Yazd, Iran;2. Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;3. Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;4. Department of Biological Sciences, Faculty of Engineering and Science, Science and Arts University, Yazd, Iran;1. Department of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany;2. Physikalisch-Technische Bundesanstalt (PTB), Bundesallee 100, 38116 Braunschweig, Germany |
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| Abstract: | Acute disseminated encephalomyelitis, an inflammatory and demyelinating disorder of central nervous system white matter, typically occurs following childhood viral infections. Although CT may demonstrate abnormalities, many children have normal CT studies in spite of widespread neurologic abnormalities. We report a series of five patients with the typical clinical presentation of disseminated encephalomyelitis who were studied using magnetic resonance imaging (MRI). In each case the children presented with progressive subacute neurologic abnormalities including headache, diplopia, ataxia, hemiparesis, seizures, dysarthria, and/or coma. CT was nondiagnostic. MRI clearly demonstrated multifocal white matter lesions of the cerebrum, brainstem, and cerebellum which corresponded to clinical signs. The patients improved dramatically with corticosteroid therapy. MRI showed progressive resolution of multifocal lesions in conjunction with clinical improvement. |
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