Preparation of some new derivatives of (1R,2S)-1,2-diphenyl-2-aminoethanol and enantioselective borane reduction of propiophenone

Some new methylated and N-alkylated derivatives of (1R,2S)-1,2-diphenyl-2-amino ethanol were synthesized and applied to enantioselective borane reduction of propiophenone. The relationship between catalyst structure and enantioselectivity was discussed in detail.