Synthesis and structure of mycolactone E isolated from frog mycobacterium |
| |
| Authors: | Aubry Sylvain Lee Richard E Mahrous Engy A Small Pam L C Beachboard Dia Kishi Yoshito |
| |
| Institution: | Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. |
| |
| Abstract: | The structure of mycolactone E, isolated from the frog pathogen Mycobacterium liflandii, was established via organic synthesis. Within the mycolactone family of metabolites, a structural variation has been seen only at the unsaturated fatty acid moiety thus far, and mycolactone E follows this observation. Interestingly, the absolute configuration of its unsaturated fatty acid matches that of the mycolactones from human mycobacteria, rather than the structurally more closely related mycolactone F from fish mycobacteria. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
