Highly (E)-selective Wadsworth-Emmons reactions promoted by methylmagnesium bromide |
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| Authors: | Claridge Timothy D W Davies Stephen G Lee James A Nicholson Rebecca L Roberts Paul M Russell Angela J Smith Andrew D Toms Steven M |
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| Institution: | Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK. |
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| Abstract: | An experimentally simple protocol for the very highly (E)-selective Wadsworth-Emmons reaction (E):(Z) selectivities in excess of 180:1 in some cases] of a range of straight-chain and branched aliphatic, substituted aromatic, and base-sensitive aldehydes via reaction with an alkyl diethylphosphonoacetate and MeMgBr is reported. |
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