MWNT-modified electrodes for voltammetric determination of lipophilic vitamins |
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Authors: | Guzel Ziyatdinova Mikhail Morozov Herman Budnikov |
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Affiliation: | 1. Department of Analytical Chemistry, Kazan (Volga Region) Federal University, Kremlyevskaya, 18, Kazan, 420008, Russian Federation 2. Department of Physics, Kazan (Volga Region) Federal University, Kremlyevskaya, 18, Kazan, 420008, Russian Federation
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Abstract: | Multi-walled carbon nanotube modified graphite electrodes (MWNT-GEs) have been created for the voltammetric determination of α-tocopherol and retinol. The electrode surface was characterized by atomic force microscopy. The MWNT-GEs presented structured surfaces and a significant (26-fold) increase in roughness over unmodified graphite electrodes (8.2 vs. 0.32?nm for MWNT-GEs and GEs, respectively). Their surfaces consisted of aggregates with a highly regular “thorn-like” structure. α-Tocopherol and retinol were oxidized on the bare GEs and the MWNT-GEs in 0.1?M HClO4 in acetonitrile. Decreases in the overpotential of 0.2 and 0.04?V for α-tocopherol and retinol, respectively, and increased oxidation currents were observed on the MWNT-GEs in comparison with the unmodified electrodes. The calibration graphs were linear in the range 0.065–2.00?mM for α-tocopherol and 0.05–1.50?mM for retinol. The detection limits were found to be 0.05 and 0.04?mM for α-tocopherol and retinol, respectively. The developed electrodes were applied to determine α-tocopherol and retinol in pharmaceuticals. The results obtained agreed well with coulometric titration data. |
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