Identification of solvents of abuse using gas chromatography/Fourier transform infrared spectrometry after headspace sampling |
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Authors: | M Deveaux J -P Huvenne |
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Institution: | (1) Institut de Médecine Légale et de Médecine Sociale, Place Théo Varlet, F-59000 Lille, France;(2) Centre Universitaire de Mesure et d'Analyse, 3, rue du Professeur Laguesse, F-59045 Lille Cedex, France |
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Abstract: | Summary After experimental intoxication of rats, gas chromatography — Fourier transform infrared spectrometry with headspace sampling (HS/GC/FT-IR) was used to identify solvents of abuse in biological material (blood, liver, lungs and brain). Limits of detection were measured for acetone, 2-butanone, ether, toluene and trichlorethylene with standard solutions. All the solvents have been identified in the organs of the intoxicated rats. For blood samples a salting-out effect was obtained with potassium carbonate. HS/GC/FT-IR allowed the identification of metabolites of acetone (isopropanol) and of 2-butanone (2-butanol) in blood and organs. |
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Keywords: | Gas chromatography Fourier transform IR detection Headspace sampling Solvents of abuse |
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