Simple and efficient synthesis of substituted 2-pyrrolidinones, 2-pyrrolones, and pyrrolidines from enaminones of Baylis-Hillman derivatives of 3-isoxazolecarbaldehydes |
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| Authors: | Singh Vijay Saxena Rashmi Batra Sanjay |
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| Institution: | Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India. |
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| Abstract: | The enaminones, generated from derivatives of appropriately substituted Baylis-Hillman adducts of 3-isoxazolecarbaldehydes, undergo intramolecular ring-closure reactions to afford substituted 2-pyrrolidinones, 1,5-dihydro-2-pyrrolones, and N-substituted pyrrolidines in good yields. |
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