Amino acids and peptides. XIII. Synthetic studies on N-terminal tripeptide amide analogs of fibrin alpha-chain |
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| Authors: | K Kawasaki T Tsuji K Hirase M Miyano Y Imoto M Iwamoto |
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| Institution: | Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan. |
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| Abstract: | N-Terminal tripeptide analogs of fibrin alpha-chain were synthesized and their inhibitory effect on fibrinogen/thrombin clotting was examined. A new water-soluble active ester, 3-pyridinium ester, was used for the synthesis. Among the synthetic peptides, H-Gly-Pro-Arg-hexamethyleneimine exhibited the highest inhibitory effect on fibrinogen-thrombin clotting. |
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