Dynamics and thermodynamics of dimerization of parallel G-quadruplexed DNA formed from d(TTAGn) (n=3-5) |
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Authors: | Kato Yoshitake Ohyama Takako Mita Hajime Yamamoto Yasuhiko |
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Affiliation: | Department of Chemistry, University of Tsukuba, Tsukuba 305-8571, Japan. |
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Abstract: | Parallel G-quadruplexes formed from oligonucleotide sequences, d(TTAGn), where n = 3-5, have been shown to form a dimer through end-to-end stacking of 3'-terminal G-tetrads. The monomers and dimers of the G-quadruplexes are in dynamic equilibrium with an exchange rate of approximately 1 s-1. A thermodynamic study demonstrated that the dimerization of the G-quadruplexes is largely enthalpic in origin. |
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