Highly regioselective synthesis of chiral diamines via a Buchwald–Hartwig amination from camphoric acid and their application in the Henry reaction |
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Authors: | Magdalena Uzarewicz‐Baig Maximilian Koppenwallner Sobia Tabassum René Wilhelm |
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Institution: | Department of Chemistry, University of Paderborn, Paderborn, Germany |
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Abstract: | In this work the synthesis of new asymmetric diamine ligands from camphoric acid is described. The new diamines can be directly prepared in a regioselective arylation of the less hindered primary amine group of (+)‐cis‐1,2,2‐trimethylcyclopentane‐1,3‐diamine via a Buchwald–Hartwig amination in high yields. The resulting diamines incorporate a secondary and primary amine group and were successfully applied as ligands in a copper‐catalyzed Henry reaction. Copyright © 2014 John Wiley & Sons, Ltd. |
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Keywords: | Buchwald– Hartwig amination palladium diamines camphor Henry reaction |
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