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A Mild Dihydrobenzooxaphosphole Oxazoline/Iridium Catalytic System for Asymmetric Hydrogenation of Unfunctionalized Dialins |
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| Authors: | Dr. Bo Qu Dr. Lalith P. Samankumara Dr. Shengli Ma Dr. Keith R. Fandrick Dr. Jean‐Nicolas Desrosiers Dr. Sonia Rodriguez Dr. Zhibin Li Dr. Nizar Haddad Dr. Zhengxu S. Han Keith McKellop Scott Pennino Dr. Nelu Grinberg Dr. Nina C. Gonnella Dr. Jinhua J. Song Dr. Chris H. Senanayake |
| Affiliation: | Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc. 900 Ridgebury Road, Ridgefield, CT 06877‐0368 (USA) |
| Abstract: | Air‐stable P‐chiral dihydrobenzooxaphosphole oxazoline ligands were designed and synthesized. When they were used in the iridium‐catalyzed asymmetric hydrogenation of unfunctionalized 1‐aryl‐3,4‐dihydronaphthalenes under one atmosphere pressure of H2, up to 99:1 e.r. was obtained. High enantioselectivities were also observed in the reduction of the exocyclic imine derivatives of 1‐tetralones. |
| Keywords: | asymmetric catalysis imines iridium P,N ligands reduction |