Structure–activity relationship of N‐heterocyclic carbene–Pd(II)–imidazole complexes in Suzuki–Miyaura coupling between 4‐methoxyphenyl chloride and phenylboronic acid |
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Authors: | Huan Lv Lei Zhu Yi‐Qiang Tang Jian‐Mei Lu |
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Affiliation: | College of Chemistry and Materials Engineering, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang Province, People's Republic of China |
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Abstract: | A series of N‐heterocyclic carbene–PdCl2–imidazole [NHC–Pd(II)–Im] complexes were synthesized and the structure of most of them was unambiguously determined by X‐ray single‐crystal diffraction. The structure–activity relationship of these complexes was investigated for the Suzuki–Miyaura coupling between 4‐methoxyphenyl chloride and phenylboronic acid, and the effect of the NHCs and Im moieties were fully discussed. The sterically hindered IPr‐based complex showed the highest catalytic activity. Copyright © 2013 John Wiley & Sons, Ltd. |
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Keywords: | N‐heterocyclic carbene palladium complex imidazole structure– activity relationship Suzuki– Miyaura coupling |
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