Palladium‐catalyzed direct arylation of polyfluoroarene and facile synthesis of liquid crystal compounds |
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| Authors: | Xiaowei Ma Yan Liu Ping Liu Jianwei Xie Bin Dai Zhiyong Liu |
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| Institution: | 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, China;2. School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi, China |
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| Abstract: | A convenient approach has been developed to prepare polyfluorobiphenyl by Pd(OAc)2/PCy3‐catalyzed direct arylation of polyfluoroarenes with aromatic halides in the presence of Cs2CO3 as base and toluene as solvent. In most cases, the desired arylated products of aromatic bromides were obtained in good to excellent yield at 80°C, and aryl chlorides also gave modest to good yields of arylated products at 110°C. According to this efficient C―C bondforming method, polyfluorobiphenyl liquid crystal compounds were prepared by Pd‐catalyzed direct arylation reactions of polyfluoroarenes with long alkyl chain substituted aryl bromides in 62–96% yield. Copyright © 2014 John Wiley & Sons, Ltd. |
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| Keywords: | palladium arylation polyfluoroarenes C― H activation liquid crystal compounds |
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