Enantioselective divergent approaches to both (−)-platensimycin and (−)-platencin |
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| Authors: | Sho HiraiMasahisa Nakada |
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| Institution: | Department of Chemistry and Biochemistry, ASE Graduate School, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan |
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| Abstract: | Enantioselective divergent approaches to (−)-platencin and (−)-platensimycin have been developed. A rationally designed chiral synthetic intermediate, possessing a useful α,β-unsaturated sulfone functionality, which served as a masked ketone as well as a good Michael acceptor, was successfully prepared via the highly enantioselective catalytic asymmetric intramolecular cyclopropanation (CAIMCP) developed in our laboratory. |
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| Keywords: | Asymmetric catalysis Cyclopropanation Divergent approaches Enantioselective synthesis |
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