| Intramolecular stacking interaction in mixed-ligand complexes containing ATP4- and aromatic N-heterocyclic ligands |
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| 引用本文： | 乐学义,毋福海,贺小凤,宋粉云,计亮年. Intramolecular stacking interaction in mixed-ligand complexes containing ATP4- and aromatic N-heterocyclic ligands[J]. 中国化学, 1998, 16(4): 356-362. DOI: 10.1002/cjoc.19980160410 |
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| 作者姓名： | 乐学义 毋福海 贺小凤 宋粉云 计亮年 |
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| 作者单位： | College of Sciences，South China Agricultural University，Guangzhou，Guangdong 510642，China，Department of Hygienics，Guangdong Pharmaceutical School，Guangzhou，Guangdong 510224，China，Department of Chemistry，Zhongshan University，Guangzhou，Guangdong 510275，China，Department of Hygienics，Guangdong Pharmaceutical School，Guangzhou，Guangdong 510224，China，Department of Chemistry，Zhongshan University，Guangzhou，Guangdong 510275，China |
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| 基金项目： | Project (No. 29170038) supported by the National Natural Science Foundation of China |
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| 摘 要： | The stability constants of the binary ML2+ and ternary M(ATP)L2- complexes,where L=Iq (isoquinoline) or BIm (benzimidazole) and M=Zn2+ or Cd2+,have been determined by poten-tiometric pH titration in aqueous solution at I=0.1 mol/L (NaClO4),T=25℃.The stability of the ternary complexes characterized by corresponding to the equilibrium M(ATP)2-+ML2+=M(ATP)L2-+M2+ is higher than what would be expected on statistical grounds.The increase may be related to the stacking interaction between the aromatic ring of the ligands L and the purine moiety of ATP4- 1H NMR studies of Zn2+/ATP4-/L confirm the presence of stacking in the ternary complexes.It is concluded that the strength of the intramolecular stacking interaction is dependent on the structure of the aromatic ring of the ligand L and the formation of a metal ion bridge.Possible implications are discussed briefly.
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Intramolecular stacking interaction in mixed-ligand complexes containing ATP4- and aromatic N-heterocyclic ligands |
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| LE,Xue-Yi WU,Fu-HaiHE,Xiao-Feng SONG,Fen-Yun JI,Liang-NianCollege of Sciences,South China Agricultural University,Guangzhou,Guangdong ,China. Intramolecular stacking interaction in mixed-ligand complexes containing ATP4- and aromatic N-heterocyclic ligands[J]. Chinese Journal of Chemistry, 1998, 16(4): 356-362. DOI: 10.1002/cjoc.19980160410 |
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| Authors: | LE Xue-Yi WU Fu-HaiHE Xiao-Feng SONG Fen-Yun JI Liang-NianCollege of Sciences South China Agricultural University Guangzhou Guangdong China |
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| Affiliation: | LE,Xue-Yi WU,Fu-HaiHE,Xiao-Feng SONG,Fen-Yun JI,Liang-NianCollege of Sciences,South China Agricultural University,Guangzhou,Guangdong 510642,ChinaDepartment of Hygienics,Guangdong Pharmaceutical School,Guangzhou,Guangdong 510224,ChinaDepartment of Chemistry,Zhongshan University,Guangzhou,Guangdong 510275,China |
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| Abstract: | The stability constants of the binary ML2+ and ternary M(ATP)L2? complexes, where L=Iq (isoquinoline) or BIm (benzimidazole) and M=Zn2+ or Cd2+, have been determined by potentiometric pH titration in aqueous solution at I=0.1 mol/L (NaClO4), T=25°C. The stability of the ternary complexes characterized by ΔlogKM=logKM(ATP)LM(ATP)L- logKMML corresponding to the equilibrium M(ATP)2? + ML2+ = M(ATP)L2? + M2+ in higher than what would be expected on statistical grounds. The increase may be related to the stacking interaction between the aromatic ring of the ligands L and the purine moiety of ATP4–. 1H NMR studies of Zn2+/ATP4?/L confirm the presence of stacking in the ternary complexes. It is concluded that the strength of the intramolecular stacking interaction ia dependent on the structure of the aromatic ring of the ligand L and the formation of a metal ion bridge. Possible implications an discussed briefly. |
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| Keywords: | Stacking interaction mixed-ligand complexes aromatic N-heterocyclic ligands ATP4- stability constants |
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