Modified normal-phase ion-pair chromatographic methods for the facile separation and purification of imidazolium-based ionic compounds |
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| Authors: | Nathaniel D UrbanMagdalene R Schenkel Lily A RobertsonRichard D Noble Douglas L Gin |
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| Institution: | a Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA
b Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA |
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| Abstract: | Imidazolium- and oligo(imidazolium)-based ionic organic compounds are important in the design of room-temperature ionic liquid materials; however, the chromatographic analysis and separation of such compounds are often difficult. A convenient and inexpensive method for effective thin-layer chromatography (TLC) analysis and column chromatography separation of imidazolium-based ionic compounds is presented. Normal-phase ion-pair TLC is used to effectively analyze homologous mixtures of these ionic compounds. Subsequent separation of the mixtures is performed using ion-pair flash chromatography on normal-phase silica gel, yielding high levels of recovery. This method also results in a complete exchange of the counter anion on the imidazolium compounds to the anion of the ion-pair reagent. |
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| Keywords: | Normal-phase silica gel Ion-pair chromatography Imidazolium Ionic liquid |
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