First synthesis of 4-aminopyrido[2′,3′:4,5]furo[3,2-d]pyrimidines |
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| Authors: | Yvonnick LoidreauPascal Marchand,Carole Dubouilh-BenardMarie-René e Nourrisson,Muriel DuflosThierry Besson |
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| Affiliation: | a Université de Rouen, CNRS UMR 6014—C.O.B.R.A. & FR3038, I.R.C.O.F. Rue Tesnière, 76130 Mont Saint-Aignan, France
b Université de Nantes, Nantes Atlantique Universités, Laboratoire de Chimie Thérapeutique, Cibles et Médicaments des Infections, de l’Immunité et du Cancer, IICiMed UPRES EA 1155, UFR de Sciences Pharmaceutiques et Biologiques, 1 Rue Gaston Veil, 44035 Nantes, France |
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| Abstract: | This Letter describes for the first time the synthesis of pyrido[2′,3′:4,5]furo[3,2-d]pyrimidines substituted by a primary or secondary amino group on position 4 of the pyrimidine ring. Application of microwave irradiation technology allowed fast and convenient procedures. |
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| Keywords: | Pyrido[2&prime ,3&prime :4,5]furo[3,2-d]pyrimidines Microwave-assisted chemistry Dimroth rearrangement |
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