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A new chiral sulfinyl-NH-pyridine ligand for Ir-catalyzed asymmetric transfer hydrogenation reaction |
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| Authors: | Lei Tang Qiwei WangJuanjuan Wang Zechao Lin Xiaobei Wang Linfeng CunWeicheng Yuan Jin ZhuJian Liao Jingen Deng |
| Institution: | a Key Laboratory for Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China b Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China c Graduate School of Chinese Academy of Sciences, Beijing 100049, China d Natural Products Research Center, Chengdu Institute of Biology & Chinese Academy of Sciences, Chengdu 610041, China |
| Abstract: | A new flexible C1-symmetric tridentate ligand (S)-N-(2-(tert-butylsulfinyl)benzyl)-1-(pyridin-2-yl)methanamine sulfoxide (L1) was successfully prepared and utilized as a chiral ligand for Ir(I)-catalyzed ATH (asymmetric transfer hydrogenation) reactions. Without any cooperation of other chiral center, encouraging ee and conversion values have been achieved, which provide us a better understanding on these types of ligands and a new strategy to develop new high-efficiency chiral catalysts for asymmetric reaction. |
| Keywords: | Chiral tert-butylsulfinyl moiety Weak coordination Flexible tridentate ligands ATH reaction |
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