A one-pot, three-component synthesis of thiazolidine-2-thiones |
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| Authors: | Azim Ziyaei-Halimehjani Katayoun MarjaniAkram Ashouri |
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| Affiliation: | Faculty of Chemistry, Tarbiat Moallem University, 49 Mofateh St., Tehran, Iran |
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| Abstract: | An efficient method for the synthesis of thiazolidine-2-thiones is described via regiospecific iodocyclization of an allyl amine, carbon disulfide, and iodine. Dehydrohalogenation of the iodo-derivatives gives thiazole-2(3H)-thiones. In addition, nucleophilic substitution of the iodine in the products is accomplished using NaN3, thiophenol, or dithiocarbamate. |
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| Keywords: | Thiazolidine-2-thione Regiospecific Iodocyclization Dehydrohalogenation Nucleophilic substitution |
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