Approach to highly functionalized oxazolones by a Pd-catalyzed cyclization of <em>N</em>-alkynyl <em>tert</em>-butyloxycarbamates期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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*Approach to highly functionalized oxazolones by a Pd-catalyzed cyclization of N-alkynyl tert-butyloxycarbamates*

Authors:	Zenghui LuXiaowei Xu Zhaozhen YangLichun Kong Gangguo Zhu

Institution:	Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China

Abstract:	A mild and operationally simple approach to highly functionalized oxazolones has been developed, which involves an intramolecular oxypalladation of N-alkynyl tert-butyloxycarbamates, followed by either protonolysis of the alkenyl C-Pd bond to afford 3,5-disubstituted oxazolones or allylation with allyl halides in the presence of Ag₂CO₃ to generate 3,4,5-trisubstituted oxazolones, respectively.

Keywords:	Oxazolones N-Alkynyl tert-butyloxycarbamates Palladium Oxypalladation Allyl halides
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