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Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus |
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| Authors: | Eunice MolinarNivia Rios Carmenza SpadaforaA Elizabeth Arnold Phyllis D Coley Thomas A Kursar William H GerwickLuis Cubilla-Rios |
| Institution: | a Laboratory of Tropical Bioorganic Chemistry, Faculty of Natural Exact Sciences and Technology, University of Panamá, Panama b Institute for Advanced Scientific Investigation and High Technology Services, National Secretariat of Science, Technology, and Innovation, City of Knowledge, Panama c School of Plant Sciences, The University of Arizona, Tucson, AZ 85721, USA d Department of Biology, University of Utah, Salt Lake City, Utah, USA e Smithsonian Tropical Research Institute, Unit 0948, APO AA 34002-0948, Panamá f Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA |
| Abstract: | Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites ‘coibanoles A-C’ in reference to Coiba Island and Coiba National Park, Panamá, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL. |
| Keywords: | Pycnoporus Trypanosoma Leishmania Meroterpenoids Coibanoles |
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