Al(OTf)3: an efficient recyclable catalyst for direct nucleophilic substitution of the hydroxy group of propargylic alcohols with carbon- and heteroatom-centered nucleophiles to construct C-C, C-O, C-N and C-S bonds |
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| Authors: | Mukut GohainCharlene Marais Barend CB Bezuidenhoudt |
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| Institution: | Department of Chemistry, University of the Free State, PO Box 339, Bloemfontein 9300, South Africa |
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| Abstract: | A general and highly efficient Al(OTf)3-catalyzed methodology has been developed for the direct nucleophilic substitution of the hydroxy group in propargylic alcohols with a variety of carbon- and heteroatom-centered nucleophiles such as alcohols, aromatic compounds, amides, and thiols, leading to the construction of C-C, C-O, C-N and C-S bonds. |
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| Keywords: | Aluminum triflate Propargylic alcohols Nucleophiles Regioselectivity |
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