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Exploration of polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline (PS-IIDQ) as new coupling agent for the synthesis of 8-substituted xanthine derivatives |
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| Authors: | Prabal BandyopadhyayManisha Sathe Pratibha SharmaMP Kaushik |
| Institution: | a Process Technology Development Division, Defence R&D Establishment, Jhansi Road, Gwalior 474 002, MP, India b School of Chemical Sciences, Devi Ahilya University, Khandwa Road, Indore 452 001, MP, India |
| Abstract: | Polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline (PS-IIDQ), a polymer supported covalent coupling reagent, was successfully employed for the first time in the synthesis of 8-substituted xanthine derivatives. PS-IIDQ was observed to be more efficient than IIDQ and polymer-supported carbodiimide (PS-EDC). |
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