Synthesis of sterically hindered ketones from aldehydes via O-silyl oximes |
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| Authors: | Joong-Gon KimMithilesh Kumar Mishra Doo Ok Jang |
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| Institution: | a Department of Chemistry, Yonsei University, Wonju 220-710, Republic of Korea
b Biotechnology Division, Hanwha Chemical R&D Center, Daejeon 305-345, Republic of Korea |
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| Abstract: | A mild and efficient method to synthesize sterically hindered ketones from aldehydes via O-silyl oximes was developed. Treatment of O-triphenylsilylated oximes with alkyl iodides in the presence of triethyl borane afforded the corresponding ketones. |
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| Keywords: | Ketone Aldehyde Triethyl borane O-triphenylsilylated oxime |
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