|
|||||
|
|
Biocatalytic production of tetrahydroisoquinolines |
|
| Authors: | Ruff Bettina M Bräse S O'Connor Sarah E |
| Affiliation: | a Massachusetts Institute of Technology, Department of Chemistry, 77 Massachusetts Avenue, Cambridge, MA 02139, USA b Karlsruhe Institute of Technology, Institute of Organic Chemistry, Fritz-Haber-Weg 6, 76137 Karlsruhe, Germany c The John Innes Centre, Department of Biological Chemistry, Norwich NR4 7UH, UK d The University of East Anglia, Norwich NR4 7TJ, UK |
| Abstract: | The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids. |
| Keywords: | Biocatalysis Pictet-Spengler reaction Norcoclaurine synthase Tetrahydroisoquinoline alkaloids |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |