Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp. |
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| Authors: | Ritesh RajuAndrew M Piggott Zeinab KhalilPaul V Bernhardt Robert J Capon |
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| Institution: | a Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia
b School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD 4072, Australia |
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| Abstract: | Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and X-ray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC50 = 18 and 14 μM, respectively). |
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| Keywords: | GYBQYXANPDPLKQ-DJQZFUDLSA-N |
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