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Application of [BoPhoz Rh] catalysts in the asymmetric hydrogenation of a pyridyl benzothiophene alkene |
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| Authors: | Timothy Gross Shine ChouAlan Dyke Beatriz DominguezMichelle Groarke Jonathan Medlock Michael OuelletteJayachandra P. Reddy Andreas SegerScott Zook Antonio Zanotti-Gerosa |
| Affiliation: | a Neurocrine Biosciences Inc., 12780 El Camino Real, San Diego, CA 92130, USA b Johnson Matthey Catalysis and Chiral Technologies, Unit 28, Cambridge Science Park, Milton Road, Cambridge, United Kingdom |
| Abstract: | The asymmetric hydrogenation of a pyridyl benzothiophene alkene has been successfully accomplished using [BoPhoz Rh] catalysts. By tailoring the steric properties of the BoPhoz ligand, the ee of the product could be increased from just 12% to 90%. This research further expands the substrate scope of the conventional class of functionalized alkenes amenable to catalytic asymmetric hydrogenation. |
| Keywords: | Homogeneous asymmetric hydrogenation Rhodium catalysts BoPhoz ligands Enantioselective hydrogenation of alkenes |
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