Synthesis and properties of 2-substituted 1-aryl-7,8-dihydro-6H-pyrimido[4,5-b]pyrindine-4-ones |
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Authors: | R N Galeeva M Yu Gavrilov E V Feshina M E Kon'shin |
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Abstract: | In reaction with acylating agents, 2-aryl-2-methyl-7,8-dihydro-6H-pyrimido4,5-b]pyrindin-4-ones are acylated at the methyl group and also enter into reaction with diethyl oxalate. 1-Aryl-2-phenacyl-7,8-dihydro-6H-pyrimido4,5-b]pyrindin-4-ones undergo dehydration under the influence of concentrated sulfuric acid. On the basis of the PMR and UV spectra, it was concluded that 1-aryl-2-acetonyl(phenacyl)-7,8-dihydro-6H-pyrimido4,5-b]pyrindin-4-ones exist in two tautomeric forms with strong intramolecular hydrogen bonds of the chelate type — enaminocarbonyl and enol. |
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