| 肝糖选择剂-毛细管电泳手性拆分盐酸度洛西汀对映体及分离机制 |
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| 引用本文： | 朱粉霞,杜迎翔,陈家全,于涛,周莹,陈王露,孙慧姝,杜钒. 肝糖选择剂-毛细管电泳手性拆分盐酸度洛西汀对映体及分离机制[J]. 分析化学, 2009, 37(6) |
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| 作者姓名： | 朱粉霞 杜迎翔 陈家全 于涛 周莹 陈王露 孙慧姝 杜钒 |
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| 作者单位： | 1. 中国药科大学分析化学教研室
2. 中国药科大学分析化学教研室;药物质量与安全预警教育部重点实验室;现代中药教育部重点实验室,南京,210009 |
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| 基金项目： | 教育部新世纪优秀人才，国家基础科学人才培养基金 |
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| 摘 要： | 以肝糖为毛细管电泳手性选择剂,对盐酸度洛西汀对映体的分离进行研究,建立了拆分方法.考察了手性选择剂浓度、运行缓冲液的离子强度、pH值及分离电压对手性分离的影响.在3.0% (m/V)肝糖、50 mmol/L Tris-H3PO4(pH 3.0)的运行缓冲液中,分离电压25 kV时,盐酸度洛西汀两对映体分离度达1.84.对分离机制进行了初步探讨.
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| 关 键 词： | 毛细管电泳 盐酸度洛西汀 肝糖 手性分离 |
Enantioseparation of Duloxetine Hydrochloride by Capillary Electrophoresis with Glycogen as Chiral Selector and Its Separation Mechanism |
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| ZHU Fen-Xia,DU Ying-Xiang,CHEN Jia-Quan,YU Tao,ZHOU Ying,CHEN Wang-Lu,SUN Hui-Shu,DU Fan. Enantioseparation of Duloxetine Hydrochloride by Capillary Electrophoresis with Glycogen as Chiral Selector and Its Separation Mechanism[J]. Chinese Journal of Analytical Chemistry, 2009, 37(6) |
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| Authors: | ZHU Fen-Xia DU Ying-Xiang CHEN Jia-Quan YU Tao ZHOU Ying CHEN Wang-Lu SUN Hui-Shu DU Fan |
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| Affiliation: | Department of Analytical Chemistry;China Pharmaceutical University;Nanjing 210009;Key Laboratory of Drug Quality Control and Pharmacovigilance;Ministry of Education;Nanjing 210009;Key Laboratory of Modern Chinese Medicines;Nanjing 210009 |
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| Abstract: | The chiral separation of duloxetine hydrochloride enantiomers by capillary electrophoresis was studied with glycogen as a novel chiral selector.A new method for enantioseparation was developed.The influences of the concentration and pH of buffer solution,glycogen concentration in the background electrolyte and separation voltage were investigated.The optimum conditions were obtained with 25 kV as separation voltage,3.0%(m/V) glycogen in 50 mmol/L Tris-H3PO4(pH 3.0)as running buffer.Under optimum conditions,... |
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| Keywords: | Capillary electrophoresis duloxetine hydrochloride glycogen enantioseparation |
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