Solid-phase synthesis of substituted alkynes using the Nicholas reaction |
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| Authors: | Cassel Johan A Leue Stefanie Gachkova Natalie I Kann Nina C |
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| Institution: | Department of Organic Chemistry, Chalmers University of Technology, SE-412 96 G?teborg, Sweden. nina.kann@oc.chalmers.se |
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| Abstract: | The first example of a Nicholas reaction on solid phase is reported, involving the reaction of cobalt complexes of polymer-bound alkynols with different nucleophiles in the presence of a Lewis acid, to form carbon-oxygen or carbon-carbon bonds. |
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