Highly enantioselective synthesis of alpha,alpha-disubstituted malonamic acids through asymmetric hydrolysis of dinitriles with Rhodococcus sp. CGMCC 0497 |
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| Authors: | Wu Zhong-Liu Li Zu-Yi |
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| Institution: | State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China. |
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| Abstract: | Highly enantioselective hydrolysis of alpha,alpha-disubstituted malononitriles by the strain Rhodococcus sp. CGMCC 0497 expressing both nitrile hydratase and amidase activity to give (R)-alpha,alpha-disubstituted malonamic acids which could be converted to valuable (R)- or (S)-alpha-alkylated amino acids are reported and the yields of the products are improved remarkably at a lower reaction temperature. |
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