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Binding of an inhibitor of the p53/MDM2 interaction to MDM2 |
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| Authors: | Duncan Sara J Cooper Matthew A Williams Dudley H |
| Affiliation: | Dept of Chemistry, Lensfield Rd, Cambridge, UK CB2 1EW. |
| Abstract: | The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2. |
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