ON THE PHOTOSENSITIZING PROPERTIES OF N-FORMYLKYNURENINE AND RELATED COMPOUNDS |
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| Authors: | Marie-Paule, Pileni ,René ,Santus Edward J.,Land |
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| Affiliation: | Laboratoire de Biophysique, Museum National d'Histoire Naturelle, 61, Rue Buffon, 75005 Paris, France;Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M 20-9 BX, U.K. |
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| Abstract: | Abstract— The photochemical and photosensitizing properties of N -formylkynurenine (FK) and related compounds have been investigated using the laser flash photolysis technique by exciting water solutions with 265 nm or 353 nm radiation. The FK molecules in their first excited singlet state readily react with water leading probably to OH formation. FK triplet state reacts with many biological compounds including vitamins, amino acids and nucleic acid bases. The semi-reduced FK thus formed can, in turn, reduce substrates such as cytochrome c or O2. |
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