Synthesis and characterization of some new Cd(II) and Zn(II) macrocyclic Schiff base complexes derived from cyclocondensation of three new linear aromatic (N4) amines and 2,6-diacetylpyridine. Crystal structure and biological activity studies |
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Authors: | Hassan Keypour Mozhdeh Liyaghati-Delshad Majid Rezaeivala Hamid Reza Khavasi |
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Institution: | 1. Faculty of Chemistry, Bu-Ali Sina University, 65174, Hamedan, Iran 2. Department of Chemical Engineering, Hamedan University of Technology, 65155, Hamedan, Iran 3. Department of Chemistry, Shahid Beheshti University, G.C., Evin, 1983963113, Tehran, Iran
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Abstract: | Six new Cd(II) and Zn(II) macrocyclic Schiff base complexes from cyclocondensation of 2,6-diacetylpyridine and three different liner aromatic amines have been investigated. The resulting ligands, L1 and L2 are 17- and L3 18-membered pentaaza macrocycles. The complexes have been characterized by a variety of methods such as IR, elemental analysis, EI-Mass and conductivity measurements and in the case of cadmium complex by 1H and 13C NMR spectroscopy. The crystal structure of CdL1(CH3OH)](ClO4)2 has been determined. In this complex, the Cd(II) ion is coordinated to five nitrogen donor atoms of the ligand and one oxygen atom from methanol in a N5O environment. The geometry around the cadmium can be better described as in a slightly distorted pentagonal-pyramidal. The synthesized compounds have antibacterial activity against the three gram-positive bacteria: S. aureus, B. cereus and C. xerosis, and also against the three gram-negative bacteria: E. coli, K. pneumoniae and P. vulgaris. The results show that the antibacterial activity of cadmium complexes is greater than that of zinc complexes. |
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