Base promoted synthesis of activated cyclopropanes bearing homologated carbonyl groups via tandem Michael addition-intramolecular enolate trapping |
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| Authors: | Russo Alessio Lattanzi Alessandra |
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| Affiliation: | Dipartimento di Chimica e Biologia, Fisciano, Italy. |
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| Abstract: | A simple base promoted intramolecular Michael initiated ring closure reaction of γ-hydroxyenone derived diphenyl phosphinates with 1,3-indandione, enabled the synthesis of novel activated cyclopropanes with homologated carbonyl moiety in good yield. Promising levels of enantioselectivity are achieved when using cinchona derivatives as promoters. |
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