A dearomatizing, thionium ion cyclization for the synthesis of functionalized, azaspirocyclic cyclohexadienones |
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| Authors: | Ovens Caroline Martin Nathaniel G Procter David J |
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| Affiliation: | School of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, United Kingdom. |
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| Abstract: | Thionium ions, generated by the addition of thiols to N-benzylglyoxamides, undergo a dearomatizing spirocyclization. The alkyl or arylsulfanyl group introduced during the thionium ion cyclization can act as a synthetic handle and a stereochemical control element during modifications of the azaspirocyclic frameworks (R(F) = CH(2)CH(2)C(8)F(17)). |
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